Mahmoud H. El Kouni: search on Z-Library

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1

Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase

John G. Niedzwicki, Max H. Iltzsch, Mahmoud H. El Kouni, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 1.08 MB

english, 1984

2

Effects of N,N-dimethylformamide and sodium butyrate on enzymes of pyrimidine metabolism in cultured human tumor cells

Fardos N.M. Naguib, John G. Niedzwicki, Max H. Iltzsch, Michael C. Wiemann, Mahmoud H. el Kouni, Sungman Cha

Journal:

Leukemia Research

Year:

1987

Language:

english

File:

PDF, 638 KB

english, 1987

3

Enzymes of uridine 5′-monophosphate biosynthesis in Schistosoma mansoni

Max H. Iltzsch, John G. Niedzwicki, Alfred W. Senft, Sungman Cha, Mahmoud H. El Kouni

Journal:

Molecular and Biochemical Parasitology

Year:

1984

Language:

english

File:

PDF, 994 KB

english, 1984

4

[Part 1: Biological Sciences] || Isolation and Partial Characterization of a 5′-nucleotidase Specific for Orotidine-5′-monophosphate

Mahmoud H. El Kouni and Sungman Cha

Journal:

Proceedings of the National Academy of Sciences

Year:

1982

Language:

english

File:

PDF, 811 KB

english, 1982

5

SYNTHESIS OF CARBOCYCLIC OROTIDINE ANALOGS AS POTENTIAL OROTIDINE DECARBOXYLASE INHIBITORS

Song, Gyu, Naguib, Fardos, el Kouni, Mahmoud, Chu, Chung

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2001

Language:

english

File:

PDF, 173 KB

english, 2001

6

5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapy

Osama M. Ashour, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.24 MB

english, 1996

7

Trends in the Design of Nucleoside Analogues as Anti-HIV Drugs

el Kouni, Mahmoud

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 83 KB

english, 2002

8

Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase

Young Ah Kim, Ravindra K. Rawal, Jakyung Yoo, Ashoke Sharon, Ashok K. Jha, Chung K. Chu, Reem H. Rais, Omar N. Al Safarjalani, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

9

5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase

John G. Niedzwicki, Shih Hsi Chu, Mahmoud H. el Kouni, Elizabeth C. Rowe, Cha Sungman

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 661 KB

english, 1982

10

Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine

Naguib, Fardos N.M., Rais, Reem H., Al Safarjalani, Omar N., el Kouni, Mahmoud H.

Journal:

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 614 KB

english, 2015

11

ChemInform Abstract: Synthesis of Carbocyclic Orotidine Analogues as Potential Orotidine Decarboxylase Inhibitors.

Gyu Y. Song, Fardos N. M. Naguib, Mahmoud H. el Kouni, Chung K. Chu

Journal:

Year:

2002

File:

PDF, 32 KB

2002

12

Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Omar N. Al Safarjalani, Xiao-Jian Zhou, Fardos N. Naguib, Naganna M. Goudgaon, Raymond F. Schinazi, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

13

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

Omar N. Al Safarjalani, Reem H. Rais, Young Ah Kim, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 388 KB

english, 2008

14

Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases

John G. Niedzwicki, Mahmoud H. El Kouni, Shih Hsi Chu, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 1.36 MB

english, 1983

15

ChemInform Abstract: Uridine Phosphorylase Inhibitors: Chemical Modification of Benzyloxybenzyl-barbituric Acid and Its Effects on UrdPase Inhibition.

David J. Guerin, Daniel Mazeas, Manoj S. Musale, Fardos N. M. Naguib, Omar N. Al Safarjalani, Mahmoud H. el Kouni, Raymond P. Panzica

Journal:

Year:

1999

File:

PDF, 29 KB

1999

16

Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine

Osama M Ashour, Fardos N.M Naguib, Raymond P Panzica, Omar N Al Safarjalani, Mahmoud H el Kouni

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

17

Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from toxoplasma gondii

Zahid Z Javaid, Mahmoud H el Kouni, Max H Iltzsch

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 275 KB

english, 1999

18

Kinetic studies of thymidine phosphorylase from mouse liver

Iltzsch, Max H., El Kouni, Mahmoud H., Cha, Sungman

Journal:

Year:

1985

Language:

english

File:

PDF, 997 KB

english, 1985

19

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Fardos N.M. Naguib, Max H. Iltzsch, Mustapha M. el Kouni, Raymond P. Panzica, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

20

Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase

Goudgaon, Naganna M., Naguib, Fardos N. M., el Kouni, Mahmoud H., Schinazi, Raymond F.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 735 KB

english, 1993

21

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

Omar N. Al Safarjalani, Reem Rais, Junxing Shi, Raymond F. Schinazi, Fardos N. M. Naguib, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 227 KB

english, 2006

22

Potential chemotherapeutic targets in the purine metabolism of parasites

Mahmoud H el Kouni

Journal:

Pharmacology & Therapeutics

Year:

2003

Language:

english

File:

PDF, 717 KB

english, 2003

23

Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil: Possible relevance to regional chemotherapy

George C. Daher, Fardos N.M. Naguib, Mahmoud H. El Kouni, Ruiwen Zhano, Seng J. Soong, Robert B. Diasio

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 844 KB

english, 1991

24

Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii

Mahmoud H. el Kouni, Fardos N.M. Naguib, Raymond P. Panzica, Brian A. Otter, Shih-Hsi Chu, Gilles Gosselin, Chung K. Chu, Raymond F. Schinazi, Y.Fulmer Shealy, Naganna Goudgaon, Alexander A. Ozerov, T

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.56 MB

english, 1996

25

Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines

Kyung Sun Park, Mahmoud H. el Kouni, Thomas A. Krenitsky, Shih Hsi Chu, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 253 KB

english, 1986

26

Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase

Ji Woong Choi, Byoung-Kwon Yoo, Chan Young Shin, Mi-Kyoung Ryu, Jong Hoon Ryu, Mahmoud H. el Kouni, Jae-Chul Lee, Won-Ki Kim, Kwang Ho Ko

Journal:

Neuroscience Research

Year:

2006

Language:

english

File:

PDF, 370 KB

english, 2006

27

Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription

Van Duyne, Rachel, Guendel, Irene, Jaworski, Elizabeth, Sampey, Gavin, Klase, Zachary, Chen, Hao, Zeng, Chen, Kovalskyy, Dmytro, el Kouni, Mahmoud H., Lepene, Benjamin, Patanarut, Alexis, Nekhai, Serg

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.56 MB

english, 2013

28

Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition

David J. Guerin, Daniel Mazeas, Manoj S. Musale, Fardos N.M. Naguib, Omar N. Al Safarjalani, Mahmoud H. el Kouni, Raymond P. Panzica

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

29

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity

Al Safarjalani, Omar N., Rais, Reem, Naguib, Fardos N. M., el Kouni, Mahmoud H.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 202 KB

english, 2012

30

Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice

Mahmoud H. el Kouni, Fardos N.M. Naguib, Park Kyung Sun, Cha Sungman, James W. Darnowskl, Seng-Jaw Soong

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 766 KB

english, 1990

31

Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides

Naguib, Fardos N.M., el Kouni, Mahmoud H.

Journal:

Molecular and Biochemical Parasitology

Year:

2014

Language:

english

File:

PDF, 288 KB

english, 2014

32

Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities

Omar N. Al Safarjalani, Reem H. Rais, Young Ah Kim, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 251 KB

english, 2010

33

6-Benzylthioinosine analogues: Promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es)

Amol Gupte, John K. Buolamwini, Vikas Yadav, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 202 KB

english, 2005

34

Combination therapy of Schistosoma japonicum by tubercidin and nitrobenzylthioinosine 5′-monophosphate

Mahmoud H. el Kouni, Paul M. Knopf, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 307 KB

english, 1985

35

Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver: Possible relevance to chemotherapy with 5-fluoropyrimidines

Fardos N.M. Naguib, Soong Seng-Jaw, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 981 KB

english, 1993

36

Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors

Mahmoud H. el Kouni, Norma J. Messier, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 853 KB

english, 1987

37

Adenosine Metabolism in Toxoplasma gondii: Potential Targets for Chemotherapy

el Kouni, Mahmoud

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 858 KB

english, 2007

38

6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

Reem H. Rais, Omar N. Al Safarjalani, Vikas Yadav, Vincenzo Guarcello, Marion Kirk, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 249 KB

english, 2005

39

Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10

Osama M Ashour, Fardos N.M Naguib, Naganna M Goudgaon, Raymond F Schinazi, Mahmoud H el Kouni

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

40

Synthesis of a new class of uridine phosphorylase inhibitors

Diane L. Levesque, Eng-Chi Wang, Dau-Chang Wei, Cherng-Chyi Tzeng, Raymond P. Panzica, Fardos N. M. Naguib, Mahmoud H. El Kouni

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 512 KB

1993

41

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents

Young Ah Kim, Ashoke Sharon, Chung K. Chu, Reem H. Rais, Omar N. Al Safarjalani, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.89 MB

english, 2007

42

Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors

Mahmoud H. el Kouni, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 935 KB

english, 1987

43

Uridine Protects Cortical Neurons from Glucose Deprivation-Induced Death: Possible Role of Uridine Phosphorylase

Choi, Ji Woong, Shin, Chan Young, Choi, Min Sik, Yoon, Seo Young, Ryu, Jong Hoon, Lee, Jae-Chul, Kim, Won-Ki, El Kouni, Mahmoud H., Ko, Kwang Ho

Journal:

Journal of Neurotrauma

Year:

2008

Language:

english

File:

PDF, 3.02 MB

english, 2008

44

Editorial [ Hot Topic: Potential Targets for the Rational Design of Antiparasitic Drugs (Executive Editor: Mahmoud H. el Kouni) ]

el Kouni, Mahmoud

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 53 KB

english, 2007

45

Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum

Naguib, Fardos N.M., Wilson, Craig M., el Kouni, Mahmoud H.

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2018

Language:

english

File:

PDF, 531 KB

english, 2018

46

Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy

Osama M. Ashour, Fardos N. M. Naguib, Naganna M. Goudgaon, Raymond F. Schinazi, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 106 KB

english, 2000

47

Nucleotidase activities of human peripheral lymphocytes

Frederick W. Burgess, Mahmoud H. El Kouni, Robert E. Parks Jr.

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 1.13 MB

english, 1985

48

Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity

Vincenzo Guarcello, Carmelo Blanquicett, Fardos N. M. Naguib, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

49

Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'- monophosphate against chronic and advanced stages of schistosomiasis

Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 703 KB

english, 1991

50

Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver

Fardos N.M. Naguib, Mahmoud H. El Kouni, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 984 KB

english, 1989

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